Lipid Profiles of ART-Experienced Patients at HIV Clinic in Harare, Zimbabwe

  • Tawanda Jonathan Chisango Chinhoyi University of Technology, Department of Biotechnology
  • Brian Pakarimwa University of Zimbabwe College of Health Sciences, Department of Medical Laboratory Sciences,
  • Danai Tavonga Zhou, Dr University of Zimbabwe College of Health Sciences, Department of Medical Laboratory Sciences

Abstract

Background
Dyslipidemia is one of the major problems in HIV-infected patients exposed to antiretroviral therapy (ART). Data on lipid
profile abnormalities induced by ART in Zimbabwe is inconsistent. The aim of this study was to assess the prevalence and
patterns of lipid profile abnormalities among patients taking ART at an HIV Clinic in Harare, Zimbabwe and hence to
assess their risk of coronary heart disease.
Methods
The study population consisted of 185 ART-experienced patients, aged between 18-68 years. Lipid profiles were
determined on serum samples and dyslipidemia was diagnosed according to National Cholesterol Education Programme
(NCEP) Adult Treatment Panel III (ATP III) reference ranges. Data between groups was compared using Pearson chisquare
tests.
Results
Approximately 78% of patients were female, mean age of the study subjects was 41±10years, all patients were on ART
and overall prevalence of dyslipidemia was 48%. There was no difference in levels of TC and LDL-C in males and females
but more males had low levels of HDL-C than females.
Conclusions
There was a high prevalence of dyslipidemia observed among the ART- experienced participants studied. This suggests
that lipid profiles should be screened in ART-exposed populations periodically to monitor any changes in lipid profiles.

Author Biographies

Tawanda Jonathan Chisango, Chinhoyi University of Technology, Department of Biotechnology

PO Box 7724, Chinhoyi, Zimbabwe

Danai Tavonga Zhou, Dr, University of Zimbabwe College of Health Sciences, Department of Medical Laboratory Sciences

P.O. Box AV 178, Avondale, Harare

Published
2018-07-31
Section
Articles